Study of certain features of the electronic structure of the ternary alloys Ni2(Mn, Fe) and Ni3(Mn, Co)

The changes in electronic structure related to transport processes occurring during the alloying of he alloy Ni3Mn with iron and cobalt, and the ordering of the ternary alloys thus formed are presented. The Hall effect, the absolute thermal emf, the internal saturation induction, the Nernst-Ettingshausen constant, and the electrical resistivity were measured. Results show a decrease in the contribution of hole sections of the Fermi surface to the transport process occurs together with a considerable increase in the contribution of electron sections. In this case, the mobility of 3 dimensional holes decreases and the mobility of 4s electrons increases considerably

Monte-Carlo simulation of clinical and economic effectiveness of drugs (on example of antibiotics therapy of acute bronchitis with bronchospasm in children)

The study objective was to determine which antibiotics are optimal in the treatment of children with complicated acute bronchitis with bronchospasm. For that, a Monte-Carlo simulation was conducte

Methodology for determining the correlation of the clinical efficacy of therapy with the addition of a drug (for example, anti-asthma therapy in children)

Methodology for determining the correlation of the clinical efficacy of therapy with the addition of a drug (on example, clinical efficacy of montelukast in an anti-asthmatic therapy in pediatric patients

The virulent Wolbachia strain wMelPop increases the frequency of apoptosis in the female germline cells of Drosophila melanogaster

<p>Abstract</p> <p>Background</p> <p><it>Wolbachia</it> are bacterial endosymbionts of many arthropod species in which they manipulate reproductive functions. The distribution of these bacteria in the <it>Drosophila</it> ovarian cells at different stages of oogenesis has been amply described. The pathways along which <it>Wolbachia</it> influences <it>Drosophila</it> oogenesis have been, so far, little studied. It is known that <it>Wolbachia</it> are abundant in the somatic stem cell niche of the <it>Drosophila</it> germarium. A checkpoint, where programmed cell death, or apoptosis, can occur, is located in region 2a/2b of the germarium, which comprises niche cells. Here we address the question whether or not the presence of <it>Wolbachia</it> in germarium cells can affect the frequency of cyst apoptosis in the checkpoint.</p> <p>Results</p> <p>Our current fluorescent microscopic observations showed that the wMel and wMelPop strains had different effects on female germline cells of <it>D. melanogaster.</it> The <it>Wolbachia</it> strain wMel did not affect the frequency of apoptosis in cells of the germarium. The presence of the <it>Wolbachia</it> strain wMelPop in the <it>D. melanogaster^w1118</it> ovaries increased the number of germaria where cells underwent apoptosis in the checkpoint. Based on the appearance in the electron microscope, there was no difference in morphological features of apoptotic cystocytes between <it>Wolbachia</it>-infected and uninfected flies. Bacteria with normal ultrastructure and large numbers of degenerating bacteria were found in the dying cyst cells.</p> <p>Conclusions</p> <p>Our current study demonstrated that the <it>Wolbachia</it> strain wMelPop affects the egg chamber formation in the <it>D. melanogaster</it> ovaries. This led to an increase in the number of germaria containing apoptotic cells. It is suggested that <it>Wolbachia</it> can adversely interfere either with the cystocyte differentiation into the oocyte or with the division of somatic stem cells giving rise to follicle cells and, as a consequence, to improper ratio of germline cells to follicle cells and, ultimately, to apoptosis of cysts. There was no similar adverse effect in <it>D. melanogaster</it> Canton S infected with the <it>Wolbachia</it> strain wMel. This was taken to mean that the observed increase in frequency of apoptosis was not the general effect of <it>Wolbachia</it> on germline cells of <it>D. melanogaster</it>, it was rather induced by the virulent <it>Wolbachia</it> strain wMelPop.</p

Theoretical research of the procrastination impact on the stress level

This article is dedicated to the overview of the procrastination concept or putting on the back burner. This is enough common phenomenon associated with delay, shift, cancellation of the significant things to do for laterСтатья посвящена обзору понятия прокрастинация или откладывание на потом. Достаточно распространенное явление, связанное с откладыванием, переносом, отменой значимых дел на пото

Can activation of TLR3 induce apoptosis in patients with miscarriages?

Objective - to estimate influence of TLR3 activation on apoptosis proteins in endometrium in patients with miscarriages and missed abortion